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Unrelieved symptoms in PNH

Unrelieved symptoms in PNH

The symptoms of PNH can be different for different individuals. Some patients have PNH in a relatively mild form while others can experience severe, debilitating symptoms.1

Despite current treatments, people with PNH may still experience debilitating symptoms caused by ongoing haemolysis.

Symptoms may include:2,3
  • Fatigue that interferes with everyday life
  • Anaemia
  • Back and abdominal pain
  • Severe headache
  • Thrombosis – blood clots
  • Haemoglobinuria – free haemoglobin, resembling blood, in urine.

Involuntary contractions of the smooth muscle in internal organs can cause further complications such as:2,3

  • Dyspnoea – difficulty breathing
  • Dysphagia – difficulty swallowing
  • In men, erectile dysfunction

References
  1. Lima M. Laboratory studies for paroxysmal nocturnal hemoglobinuria, with emphasis on flow cytometry. Pract Lab Med 2020;20.
  2. Meyers G, Weitz I, Lamy T, et al. Disease-Related Symptoms Reported across a Broad Population of Patients with Paroxysmal Nocturnal Hemoglobinuria. Blood 2007;110:3683.
  3. Mitchell R, Salkeld E, Chisolm S, et al. Path to Diagnosis of Paroxysmal Nocturnal Hemoglobinuria: The Results of an Exploratory Study Conducted by the Aplastic Anemia and MDS International Foundation and the National Organization for Rare Disorders Utilizing an Internet-Based Survey. SM Clin Med Oncol 2017;1:1001.
Abbreviations

PNH: Paroxysmal nocturnal haemoglobinuria

Job code: PP-17759 | Date of preparation: March 2023

Intended for healthcare professional only